South African second-row Hyron Andrews and Wales prop Willgriff John are part of 20 players to be leaving Sale Sharks this summer.
They join a list that includes Raffi Quirke, James Harper and Obi Ene who are all bound for Newcastle Red Bulls.
While the du Preez brothers will also depart with number eight Dan heading for Bath and back Rob moving to Top 14 side Bayonne.
“It’s been a year of transition and a year of change and a year that I know we’ll be the better for going forward,” director of rugby Alex Sanderson told the club’s website.
“But that’s on the back of the efforts and the contributions of the friends who are leaving us and have already left.”
Sale are seventh in The Prem with two games to go and will miss out on the play-offs for the first time since 2022.
Andrews, 30, will leave at the end of the season after two years in England while John, 33, has spent six seasons with Sale across two spells.
Also leaving at the end of the campaign are prop Tumy Onasanya, back-row Huw Davies, scrum-half Nye Thomas, wing Albert Bradshaw, centres Tom Curtis and Joe Bedlow and academy players Tom Davis and Frank Chatterton.
The club have also confirmed that Irish hooker Tadgh McElroy, centre Sam Bedlow, second-row Rouban Birch, scrum-half Will Wootton and prop Jack Lightbown have left with immediate effect.