Tottenham can secure their Premier League survival on Tuesday night.
However, they will have to overcome a woeful recent record against London rivals Chelsea when they travel to Stamford Bridge.
The clash had been scheduled for the weekend before being rearranged after the Blues reached the FA Cup final.
Chelsea were subsequently beaten 1-0 by Manchester City at Wembley Stadium on Saturday.
Calum McFarlane will now take charge of his final home match as interim boss against Spurs.
The Blues won the reverse fixture 1-0 in November, extending their winning run against Spurs to five matches.
Meanwhile, their opponents have not won at Stamford Bridge since April 2018, a run which spans their last nine visits.
Tuesday’s meeting will have an impact on both the race for European qualification and the relegation battle on a crucial night in west London.
Chelsea vs Tottenham: Kick-off time and how to follow
Spurs’ trip to face Chelsea will kick-off at 8.15pm on Tuesday, May 19.
The match will be broadcast live on Sky Sports Premier League, with coverage getting underway at 7pm.
Meanwhile, Natalie Sawyer will host a Kick Off Premier League special on talkSPORT, with updates from throughout the match.
She will be joined live on air by Dean Ashton, Tony Cascarino and Perry Groves.
As well as reaction to Chelsea’s clash with Spurs, they will also keep across Manchester City’s trip to Bournemouth.
To tune in through the talkSPORT website, click HERE for the livestream.
You can also listen via the talkSPORT app here, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Chelsea vs Tottenham: Relegation permutations
West Ham United will be relegated from the Premier League if Spurs beat Chelsea.
The Hammers are two points from safety with one match remaining after their defeat to Newcastle United on Sunday.
Spurs need just two points from their final two outings to ensure their own survival.
A draw with the Blues would leave Roberto De Zerbi’s side requiring just a point at home to Everton on the final day of the season.
If they lose, though, they will need to equal West Ham’s result against Leeds United.
The Hammers must beat Leeds to have any chance of survival if they are not relegated on Tuesday.
Nuno Espirito Santo’s side will need a 14-goal swing to avoid relegation if they finish level on points with Spurs.
Chelsea vs Tottenham: Team news
McFarlane confirmed in his pre-match press conference that he is waiting until after Monday’s training session to confirm the fitness of Romeo Lavia and Levi Colwill.
Meanwhile, Mamadou Sarr and Benoit Badiashile could be available after not making the squad for the FA Cup final.
Estevao and Jesse Derry remain sidelined, though, whilst Jamie Bynoe-Gittens is also ruled out.
As for Spurs, Guglielmo Vicario is fit to return to action following hernia surgery.
The Italian goalkeeper has missed Spurs’ last five matches, with Antonin Kinsky taking his place in the side.
De Zerbi has also confirmed that Dominic Solanke will miss out, but could be available to face Everton on Sunday.
James Maddison remains unable to play a full 90 minutes having trained on Sunday.
Cristian Romero, Dejan Kulusevski, Mohammed Kudus, Wilson Odobert and Xavi Simons will not feature again this season.
Chelsea vs Tottenham: What’s been said?
Speaking to reporters on Monday, McFarlane explained: “We’re very focused.
“We need to win the next two games to give ourselves the best chance to finish as high up in the league as possible and get European football.
“That is our only focus in doing our job and putting in the performance we need to.”
The Blues’ interim boss added: “Everyone knows the rivalry but both teams have a lot to play for, so I don’t think we need to do anything special.
“Both teams are fighting for the points so we shouldn’t need any extra motivation, but it will naturally be there for a London derby.”
Meanwhile, De Zerbi was asked if his players are ready to seal their Premier League survival.
The Spurs manager said: “My players have to be ready to play a good game, with pride, work on the pitch, to try to make three points to win the game, but we have to keep the balance. You have to keep the same balance in every match.”